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The St. Louis Cardinals and Pittsburgh Pirates play the second game of their four-game series when the NL Central rivals collide on Saturday at Busch Stadium in St. Louis. The Cardinals took the Opening Day game, 9-0, behind six scoreless innings from Adam Wainwright and a career-high five RBI from Tyler O’Neill. The game marked the return of Albert Pujols and the debut of 35-year-old St. Louis manager Oliver Marmol. On Saturday Miles Mikolas (2-3, 4.23 ERA last season) will start for St. Louis; he will face Pittsburgh’s Mitch Keller (5-11, 6.17).
First pitch is set for 2:15 p.m. ET. St. Louis is the -175 moneyline favorite in the latest Cardinals vs. Pirates odds from Caesars Sportsbook, while Pittsburgh is a +155 underdog. The Over/Under for total runs scored is 8.5. Before making any Pirates vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.
This model, which simulates every game 10,000 times, enters the 2022 MLB season coming off a 209-178 record on top-rated MLB picks in 2021, returning more than $700 for $100 players. Anyone following it has seen huge returns.
Now, the model has dialed in on Cardinals vs. Pirates and just locked in its picks and MLB predictions. You can only see the model’s picks only at SportsLine. Here are the MLB odds and betting lines for Pirates vs. Cardinals.
- Cardinals vs. Pirates moneyline: St. Louis -175, Pittsburgh +155
- Cardinals vs. Pirates run line: St. Louis -1.5 (+100)
- Cardinals vs. Pirates Over/Under: 8.5 runs
- STL: Paul Goldschmidt hit .500 during spring training
- PIT: Bryan Reynolds tied for the major league lead last season in triples (eight)
Why you should back the Cardinals
St. Louis looks as if it has picked up where it left off last season. Going back to last year, the Cardinals have won 22 of their last 26 games (excluding spring training games). That’s the best record in baseball over that stretch by far.
In addition, Paul Goldschmidt enters the season with a hot bat. The six-time All-Star finished spring training with a .500 batting average (11-of-22) with four home runs. In Thursday’s season opener, he drew four straight walks, becoming the first player to do that on Opening Day since Manny Ramírez in 2002.
Why you should back the Pirates
Bryan Reynolds is poised for another standout season. Last year the 27-year-old outfielder hit .302/.390/.522 with 24 home runs and 90 RBI during an All-Star season. He also tied for the major league lead with eight triples.
In addition, Pittsburgh starter Mitch Keller has the stuff to shut down the Cardinals lineup. After the average on his fastball dropped to 93.8 miles per hour last season, Keller, who regularly hit 100 mph on his fastball in the minors and averaged 95.4 mph on his fastball in 2019, overhauled his pitching mechanics in the offseason. With improved lower-body strength and flexibility and a shorter arm action on his delivery, Keller regained the triple-digit speed on his fastball.
How to make Cardinals vs. Pirates picks
SportsLine’s model is leaning Over on the run total, predicting a combined nine runs, and it also says one side of the moneyline has the value. You can only get the model’s pick at SportsLine.
So who wins Pirates vs. Cardinals? And which side of the moneyline has all the value? Visit SportsLine now to see which side of the Cardinals vs. Pirates moneyline to jump on Saturday, all from the advanced model that went 209-178 on top-rated MLB moneyline picks last year, and find out.