College football odds, picks, predictions, best bets for Week 5, 2022: Proven model likes Oklahoma, Oregon

The Week 5 college football schedule brings some especially important matchups in the SEC, ACC and Big 12. The latest Week 5 college football odds from Caesars Sportsbook list No. 14 Ole Miss as a 6.5-point favorite against No. 7 Kentucky, while No. 2 Alabama is laying 15.5 points at No. 20 Arkansas in the 3:30 p.m. ET SEC on CBS game. In the ACC, No. 23 Florida State is a 6-point favorite against No. 22 Wake Forest and No. 5 Clemson is -6.5 against No. 10 NC State in the week’s only top-10 battle.

Over in the Big 12, No. 16 Baylor is laying 2.5 points against No. 9 Oklahoma State in the latest Week 5 college football spreads as those conference title contenders meet up in Waco. Which college football lines should you be targeting this weekend? Before locking in any Week 5 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine’s advanced computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,100 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 5 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Week 5

One of the college picks the model is high on in Week 5: No. 18 Oklahoma (-5) goes on the road and covers against TCU at noon ET on Saturday. The Sooners were upset by Kansas State, a team that has been very tough on the Sooners recently, in Week 4. But the Sooners have a much better track record against the Horned Frogs. Oklahoma has won eight straight against TCU, and all but two of those wins have come by more than five points. The last two wins in the series have come by an average of 20 points.

The model sees this as a great bounce-back spot for Oklahoma as it is favored by less than a touchdown against a relatively unproven TCU squad. Dillon Gabriel throws for 300 yards in the simulations, with Marvin Mims leading the way with more than 60 receiving yards for OU. The Sooners win more than 60% of the time, making them one of the teams to include in your Week 5 college football best bets. 

Another one of the model’s top college football picks: No. 13 Oregon (-16) has no trouble with the big spread against Stanford in Saturday’s latest kickoff at 11 p.m. ET in Eugene. After being dominated in the season opener against Georgia, the Ducks have bounced back well. They’ve won three straight, highlighted by an impressive 41-20 win over a ranked BYU squad in Week 3.

Stanford, meanwhile, is 0-2 both straight up and against the spread when facing FBS competition this year. It lost both Pac-12 matchups by double digits thus far. Oregon keeps that trend rolling in the simulations, knocking the Cardinal off by 20 as it covers almost 60% of the time. See which other teams the model likes here.

How to make college football picks for Week 5

The model has also made the call on who wins and covers in every other FBS matchup in Week 5, and it says a top-10 favorite will go down hard in one of the week’s biggest games. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which top-10 favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned more than $3,100 in profit over the past six-plus seasons, and find out.

College football odds for Week 5 (via Caesars)

See full Week 5 college football picks, odds, predictions here

Thursday, Sept. 29

Utah State at BYU (-24, 60.5)

Featured Game | BYU Cougars vs. Utah State Aggies

Friday, Sept. 30

Tulane at Houston (-2.5, 55)

Featured Game | Houston Cougars vs. Tulane Green Wave

UTSA at MTSU (+5, 63)

Featured Game | Middle Tenn. Blue Raiders vs. UTSA Roadrunners

San Diego State at Boise State (-5.5, 40)

Featured Game | Boise State Broncos vs. San Diego State Aztecs

Washington at UCLA (+2.5, 65)

Featured Game | UCLA Bruins vs. Washington Huskies

New Mexico at UNLV (-16, 45.5)

Featured Game | UNLV Rebels vs. New Mexico Lobos

Saturday, Oct. 1

Michigan at Iowa (+10.5, 43)

Featured Game | Iowa Hawkeyes vs. Michigan Wolverines

Kentucky at Ole Miss (-6.5, 55.5)

Featured Game | Ole Miss Rebels vs. Kentucky Wildcats

Oklahoma at TCU (+5, 67.5)

Featured Game | TCU Horned Frogs vs. Oklahoma Sooners

Oregon State at Utah (-11, 56)

Featured Game | Utah Utes vs. Oregon State Beavers

Wake Forest at Florida State (-6, 66)

Featured Game | Florida State Seminoles vs. Wake Forest Demon Deacons

Rutgers at Ohio State (-41, 60)

Northwestern at Penn State (-25.5, 52.5)

Featured Game | Penn State Nittany Lions vs. Northwestern Wildcats

Alabama at Arkansas (+15.5, 61.5)

Featured Game | Arkansas Razorbacks vs. Alabama Crimson Tide

Oklahoma State at Baylor (-2.5, 55)

Featured Game | Baylor Bears vs. Oklahoma State Cowboys

Texas A&M at Mississippi State (-3, 46)

Featured Game | Mississippi State Bulldogs vs. Texas A&M Aggies

NC State at Clemson (-6.5, 46)

Featured Game | Clemson Tigers vs. NC State Wolfpack

Georgia at Missouri (+27.5, 55.5)

Featured Game | Missouri Tigers vs. Georgia Bulldogs

Arizona State at USC (-24, 61.5)

Featured Game | USC Trojans vs. Arizona State Sun Devils

Stanford at Oregon (-16, 62.5)

Featured Game | Oregon Ducks vs. Stanford Cardinal