Broncos vs. Colts odds, line, spread: Thursday Night Football picks, NFL predictions by model on 140-105 roll


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The Indianapolis Colts (1-2-1) will visit the Denver Broncos (2-2) on Thursday Night Football to get the Week 5 NFL schedule underway. The Broncos fell short in their last matchup to the Raiders after winning their prior two games. On the other side, the Colts lost 24-17 to the Tennessee Titans in Week 4. Both teams have major concerns at running back, with Javonte Williams (ACL) now out for the year for Denver, while Indianapolis’ Jonathan Taylor’s status is uncertain due to an ankle injury. 

Kickoff is set for 8:15 p.m. ET in Denver. Caesars Sportsbook lists Denver as a 3-point favorite in the latest Broncos vs. Colts odds. The over/under for total points is 43. Before making any Colts vs. Broncos picks, be sure to check out the NFL predictions and betting advice from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 5 of the 2022 NFL season on an incredible 140-105 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Broncos vs. Colts and just locked in its picks and TNF predictions. You can visit SportsLine now to see the model’s picks. Here are the NFL odds and betting lines for Colts vs. Broncos:

  • Broncos vs. Colts spread: Denver -3
  • Broncos vs. Colts over/under: 43 points
  • Broncos vs. Colts money line: Indianapolis +150, Denver -178
  • IND: Colts are 5-1 against the spread in their last six games following a straight-up loss
  • DEN: Broncos are 5-0 ATS in their last five home games against teams with losing road records
  • Broncos vs. Colts picks: See picks here
Featured Game | Denver Broncos vs. Indianapolis Colts

Why the Broncos can cover

Quarterback Russell Wilson is the signal-caller for Denver. The nine-time Pro Bowl selection owns a big arm and is a magician outside of the pocket. The Wisconsin product has superb mobility and deep accuracy. Through four games, he is completing 61% of his throws for 980 yards with four passing touchdowns. In his last outing, he went 17-of-25 for 237 yards and two passing scores.

Receiver Courtland Sutton continues to build rapport with Wilson. Sutton is a go-to target in the passing game with a solid leaping ability and secure hands. The 2019 Pro Bowler is a physical playmaker with outstanding size (6-foot-4, 216 pounds). He is tied for 13th in the league in receptions (24) and sixth in receiving yards (343) with a score.

Why the Colts can cover

Quarterback Matt Ryan has struggled with turnovers thus far. He is first in the NFL in fumbles (nine) while tossing five interceptions. Despite these flaws, Ryan is a savvy veteran at the helm. The Boston College product is a tough leader who still owns strong accuracy and arm strength. He is fourth in the league in passing yards (1,125) with five passing touchdowns. Last week, he went 27-of-37 for 356 yards and two passing touchdowns.

Michael Pittman Jr. is a big, smart possession receiver. Pittman Jr. owns top-notch ball skills with sticky hands to snag passes. The 2020 second-round pick takes long strides and is able to high-point the pass at will. He’s leading the team in receptions (20) and receiving yards (224) with four catches of 20-plus yards downfield. 

How to make Broncos vs. Colts picks

SportsLine’s model is leaning Under the total, calling for 42 combined points. It has also generated an against-the-spread pick that cashes in well over 50% of simulations. You can only get the model’s TNF picks at SportsLine

So who wins Colts vs. Broncos on Thursday Night Football? And which side of the spread cashes in well over 50% simulations? Visit SportsLine now to see which side of the Colts vs. Broncos spread to jump on, all from the advanced model that is up almost $7,000 on its NFL picks since 2017, and find out.

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